TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1.
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ABSTRACT:
SUBMITTER: Plescher M
PROVIDER: S-EPMC4642562 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1.
Plescher Monika M Teleman Aurelio A AA Demetriades Constantinos C
Scientific reports 20150908
mTOR complex 1 (mTORC1) regulates cell growth and metabolism. mTORC1 activity is regulated via integration of positive growth-promoting stimuli and negative stress stimuli. One stress cells confront in physiological and pathophysiological contexts is hyperosmotic stress. The mechanism by which hyperosmotic stress regulates mTORC1 activity is not well understood. We show here that mild hyperosmotic stress induces a rapid and reversible inactivation of mTORC1 via a mechanism involving multiple ups ...[more]
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