Ontology highlight
ABSTRACT:
SUBMITTER: Shao H
PROVIDER: S-EPMC4643021 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Shao Hongwei H Kong Ranran R Ferrari Massimiliano L ML Radtke Freddy F Capobianco Anthony J AJ Liu Zhao-Jun ZJ
PloS one 20151112 11
Cancer-associated fibroblasts (CAF) play a crucial role in regulating cancer progression, yet the molecular determinant that governs the tumor regulatory role of CAF remains unknown. Using a mouse melanoma model in which exogenous melanoma cells were grafted on the skin of two lines of mice where the genetic activation or inactivation of Notch1 signaling specifically occurs in natural host stromal fibroblasts, we demonstrated that Notch1 pathway activity could determine the tumor-promoting or tu ...[more]