Ontology highlight
ABSTRACT:
SUBMITTER: Mardakheh FK
PROVIDER: S-EPMC4643311 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Mardakheh Faraz K FK Paul Angela A Kümper Sandra S Sadok Amine A Paterson Hugh H Mccarthy Afshan A Yuan Yinyin Y Marshall Christopher J CJ
Developmental cell 20151101 3
Polarization of cells into a protrusive front and a retracting cell body is the hallmark of mesenchymal-like cell migration. Many mRNAs are localized to protrusions, but it is unclear to what degree mRNA localization contributes toward protrusion formation. We performed global quantitative analysis of the distributions of mRNAs, proteins, and translation rates between protrusions and the cell body by RNA sequencing (RNA-seq) and quantitative proteomics. Our results reveal local translation as a ...[more]