P38? MAPK is required for arsenic-induced cell transformation.
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ABSTRACT:
SUBMITTER: Kim HG
PROVIDER: S-EPMC4643444 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
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p38α MAPK is required for arsenic-induced cell transformation.
Kim Hong-Gyum HG Shi Chengcheng C Bode Ann M AM Dong Zigang Z
Molecular carcinogenesis 20150512 5
Arsenic exposure has been reported to cause neoplastic transformation through the activation of PcG proteins. In the present study, we show that activation of p38α mitogen-activated protein kinase (MAPK) is required for arsenic-induced neoplastic transformation. Exposure of cells to 0.5 μM arsenic increased CRE and c-Fos promoter activities that were accompanied by increases in p38α MAPK and CREB phosphorylation and expression levels concurrently with AP-1 activation. Introduction of short hairp ...[more]
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