Synthetic tools for studying the chemical biology of InsP8.
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ABSTRACT:
SUBMITTER: Riley AM
PROVIDER: S-EPMC4643724 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Synthetic tools for studying the chemical biology of InsP8.
Riley Andrew M AM Wang Huanchen H Shears Stephen B SB L Potter Barry V BV
Chemical communications (Cambridge, England) 20150801 63
To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism. ...[more]
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