Ontology highlight
ABSTRACT:
SUBMITTER: Canver MC
PROVIDER: S-EPMC4644101 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Nature 20150916 7577
Enhancers, critical determinants of cellular identity, are commonly recognized by correlative chromatin marks and gain-of-function potential, although only loss-of-function studies can demonstrate their requirement in the native genomic context. Previously, we identified an erythroid enhancer of human BCL11A, subject to common genetic variation associated with the fetal haemoglobin level, the mouse orthologue of which is necessary for erythroid BCL11A expression. Here we develop pooled clustered ...[more]