Transcriptomic Heterogeneity in Cancer as a Consequence of Dysregulation of the Gene-Gene Interaction Network.
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ABSTRACT:
SUBMITTER: van Wieringen WN
PROVIDER: S-EPMC4644214 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Transcriptomic Heterogeneity in Cancer as a Consequence of Dysregulation of the Gene-Gene Interaction Network.
van Wieringen Wessel N WN van der Vaart Aad W AW
Bulletin of mathematical biology 20150916 9
Many pathways are dysregulated in cancer. Dysregulation of the regulatory network results in less control of transcript levels in the cell. Hence, dysregulation is reflected in the heterogeneity of the transcriptome: the more dysregulated the pathway, the more the transcriptomic heterogeneity. We identify four scenarios for a transcriptomic heterogeneity increase (i.e., pathway dysregulation) in cancer: (1) activation of a molecular switch, (2) a structural change in a regulator, (3) a temporal ...[more]
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