Ontology highlight
ABSTRACT:
SUBMITTER: Schneider M
PROVIDER: S-EPMC4644235 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Cell 20150801 5
Nuclear pore complexes (NPCs) influence gene expression besides their established function in nuclear transport. The TREX-2 complex localizes to the NPC basket and affects gene-NPC interactions, transcription, and mRNA export. How TREX-2 regulates the gene expression machinery is unknown. Here, we show that TREX-2 interacts with the Mediator complex, an essential regulator of RNA Polymerase (Pol) II. Structural and biochemical studies identify a conserved region on TREX-2, which directly binds t ...[more]