Ontology highlight
ABSTRACT:
SUBMITTER: Alexander KA
PROVIDER: S-EPMC4644443 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Alexander Katherine A KA Wang Xu X Shibata Maho M Clark Andrew G AG García-García María J MJ
Cell reports 20151029 6
Genomic imprinting depends on the establishment and maintenance of DNA methylation at imprinting control regions. However, the mechanisms by which these heritable marks influence allele-specific expression are not fully understood. By analyzing maternal, zygotic, maternal-zygotic, and conditional Trim28 mutants, we found that the transcription factor TRIM28 controls genomic imprinting through distinct mechanisms at different developmental stages. During early genome-wide reprogramming, both mate ...[more]