Ontology highlight
ABSTRACT:
SUBMITTER: Mou Z
PROVIDER: S-EPMC4644471 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Mou Zongyang Z Hyde Thomas M TM Lipska Barbara K BK Martinowich Keri K Wei Peter P Ong Chiew-Jen CJ Hunter Lindsay A LA Palaguachi Gladys I GI Morgun Eva E Teng Rujia R Lai Chen C Condarco Tania A TA Demidowich Andrew P AP Krause Amanda J AJ Marshall Leslie J LJ Haack Karin K Voruganti V Saroja VS Cole Shelley A SA Butte Nancy F NF Comuzzie Anthony G AG Nalls Michael A MA Zonderman Alan B AB Singleton Andrew B AB Evans Michele K MK Martin Bronwen B Maudsley Stuart S Tsao Jack W JW Kleinman Joel E JE Yanovski Jack A JA Han Joan C JC
Cell reports 20151029 6
Brain-derived neurotrophic factor (BDNF) plays a key role in energy balance. In population studies, SNPs of the BDNF locus have been linked to obesity, but the mechanism by which these variants cause weight gain is unknown. Here, we examined human hypothalamic BDNF expression in association with 44 BDNF SNPs. We observed that the minor C allele of rs12291063 is associated with lower human ventromedial hypothalamic BDNF expression (p < 0.001) and greater adiposity in both adult and pediatric coho ...[more]