Next-generation prognostic assessment for diffuse large B-cell lymphoma.
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ABSTRACT:
SUBMITTER: Staton AD
PROVIDER: S-EPMC4644669 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Next-generation prognostic assessment for diffuse large B-cell lymphoma.
Staton Ashley D AD Koff Jean L JL Chen Qiushi Q Ayer Turgay T Flowers Christopher R CR
Future oncology (London, England) 20150820 17
Current standard of care therapy for diffuse large B-cell lymphoma (DLBCL) cures a majority of patients with additional benefit in salvage therapy and autologous stem cell transplant for patients who relapse. The next generation of prognostic models for DLBCL aims to more accurately stratify patients for novel therapies and risk-adapted treatment strategies. This review discusses the significance of host genetic and tumor genomic alterations seen in DLBCL, clinical and epidemiologic factors, and ...[more]
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