Early Life Stress Effects on Glucocorticoid-BDNF Interplay in the Hippocampus.
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ABSTRACT:
SUBMITTER: Daskalakis NP
PROVIDER: S-EPMC4644789 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Early Life Stress Effects on Glucocorticoid-BDNF Interplay in the Hippocampus.
Daskalakis Nikolaos P NP De Kloet Edo Ronald ER Yehuda Rachel R Malaspina Dolores D Kranz Thorsten M TM
Frontiers in molecular neuroscience 20151116
Early life stress (ELS) is implicated in the etiology of multiple psychiatric disorders. Important biological effects of ELS are manifested in stress-susceptible regions of the hippocampus and are partially mediated by long-term effects on glucocorticoid (GC) and/or neurotrophin signaling pathways. GC-signaling mediates the regulation of stress response to maintain homeostasis, while neurotrophin signaling plays a key role in neuronal outgrowth and is crucial for axonal guidance and synaptic int ...[more]
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