Parameterization of the Age-Dependent Whole Brain Apparent Diffusion Coefficient Histogram.

ABSTRACT:

Purpose

The distribution of apparent diffusion coefficient (ADC) values in the brain can be used to characterize age effects and pathological changes of the brain tissue. The aim of this study was the parameterization of the whole brain ADC histogram by an advanced model with influence of age considered.

Methods

Whole brain ADC histograms were calculated for all data and for seven age groups between 10 and 80 years. Modeling of the histograms was performed for two parts of the histogram separately: the brain tissue part was modeled by two Gaussian curves, while the remaining part was fitted by the sum of a Gaussian curve, a biexponential decay, and a straight line.

Results

A consistent fitting of the histograms of all age groups was possible with the proposed model.

SUBMITTER: Klose U 

PROVIDER: S-EPMC4644831 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature