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Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64.

ABSTRACT: A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, (64)Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A).

SUBMITTER: Bhatt N

PROVIDER: S-EPMC4645244 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64.

Bhatt Nikunj N Soni Nisarg N Ha Yeong Su YS Lee Woonghee W Pandya Darpan N DN Sarkar Swarbhanu S Kim Jung Young JY Lee Hochun H Kim Sun Hee SH An Gwang Il GI Yoo Jeongsoo J

ACS medicinal chemistry letters 20151020 11

A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, (64)Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A). ...[more]

PMID: 26617972

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