Human Cytomegalovirus pUL93 Is Required for Viral Genome Cleavage and Packaging.
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ABSTRACT:
SUBMITTER: DeRussy BM
PROVIDER: S-EPMC4645300 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
Human Cytomegalovirus pUL93 Is Required for Viral Genome Cleavage and Packaging.
DeRussy Bernadette M BM Tandon Ritesh R
Journal of virology 20150923 23
Human cytomegalovirus (HCMV) pUL93 is essential for virus growth, but its precise function in the virus life cycle is unknown. Here, we characterize a UL93 stop mutant virus (UL93st-TB40/E-BAC) to demonstrate that the absence of this protein does not restrict viral gene expression; however, cleavage of viral DNA into unit-length genomes as well as genome packaging is abolished. Thus, pUL93 is required for viral genome cleavage and packaging. ...[more]
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