Ontology highlight
ABSTRACT:
SUBMITTER: Walmsley S
PROVIDER: S-EPMC4645960 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Journal of acquired immune deficiency syndromes (1999) 20151201 5
The SINGLE study was a randomized, double-blind, noninferiority study that evaluated the safety and efficacy of 50 mg dolutegravir + abacavir/lamivudine versus efavirenz/tenofovir/emtricitabine in 833 ART-naive HIV-1 + participants. Of 833 randomized participants, 71% in the dolutegravir + abacavir/lamivudine arm and 63% in the efavirenz/tenofovir/emtricitabine arm maintained viral loads of <50 copies per milliliter through W144 (P = 0.01). Superior efficacy was primarily driven by fewer discont ...[more]