Ontology highlight
ABSTRACT:
SUBMITTER: Velkey JM
PROVIDER: S-EPMC4646168 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Velkey J Matthew JM O'Shea K Sue KS
Developmental dynamics : an official publication of the American Association of Anatomists 20130208 3
<h4>Background</h4>Delineating the cascades of growth and transcription factor expression that shape the developing nervous system will improve our understanding of its molecular histogenesis and suggest strategies for cell replacement therapies. In the current investigation, we examined the ability of the proneural gene, Neurogenin1 (Neurog1; also Ngn1, Neurod3), to drive differentiation of pluripotent embryonic stem cells (ESC).<h4>Results</h4>Transient expression of Neurog1 in ESC was suffici ...[more]