Ontology highlight
ABSTRACT:
SUBMITTER: Bailey CC
PROVIDER: S-EPMC4646256 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Bailey Charles C CC DeVaux Lindsey B LB Farzan Michael M
The Journal of biological chemistry 20150915 43
The triggering receptor expressed on myeloid cells 2 (TREM2) is an Ig-like V-type receptor expressed by populations of myeloid cells in the central nervous system and periphery. Loss-of-function mutations in TREM2 cause a progressive, fatal neurodegenerative disorder called Nasu-Hakola disease. In addition, a TREM2 R47H coding variant was recently identified as a risk factor for late-onset Alzheimer disease. TREM2 binds various polyanionic molecules but no specific protein ligands have been iden ...[more]