Ontology highlight
ABSTRACT:
SUBMITTER: Dai A
PROVIDER: S-EPMC4646401 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Dai Aguang A Ye Feng F Taylor Dianne W DW Hu Guiqing G Ginsberg Mark H MH Taylor Kenneth A KA
The Journal of biological chemistry 20150921 45
Increased ligand binding to integrin ("activation") underpins many biological processes, such as leukocyte trafficking, cell migration, host-pathogen interaction, and hemostasis. Integrins exist in several conformations, ranging from compact and bent to extended and open. However, the exact conformation of membrane-embedded, full-length integrin bound to its physiological macromolecular ligand is still unclear. Integrin αIIbβ3, the most abundant integrin in platelets, has been a prototype for in ...[more]