Ontology highlight
ABSTRACT:
SUBMITTER: Katsifa A
PROVIDER: S-EPMC4646642 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Katsifa Aggeliki A Kaffe Eleanna E Nikolaidou-Katsaridou Nefeli N Economides Aris N AN Newbigging Susan S McKerlie Colin C Aidinis Vassilis V
PloS one 20151116 11
Autotaxin (ATX, Enpp2) is a secreted lysophospholipase D catalysing the production of lysophosphatidic acid, a pleiotropic growth factor-like lysophospholipid. Increased ATX expression has been detected in a number of chronic inflammatory diseases and different types of cancer, while genetic interventions have proven a role for ATX in disease pathogenesis. Therefore, ATX has emerged as a potential drug target and a large number of ATX inhibitors have been developed exhibiting promising therapeut ...[more]