Ontology highlight
ABSTRACT:
SUBMITTER: Garfall AL
PROVIDER: S-EPMC4646711 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Garfall Alfred L AL Maus Marcela V MV Hwang Wei-Ting WT Lacey Simon F SF Mahnke Yolanda D YD Melenhorst J Joseph JJ Zheng Zhaohui Z Vogl Dan T DT Cohen Adam D AD Weiss Brendan M BM Dengel Karen K Kerr Naseem D S ND Bagg Adam A Levine Bruce L BL June Carl H CH Stadtmauer Edward A EA
The New England journal of medicine 20150901 11
A patient with refractory multiple myeloma received an infusion of CTL019 cells, a cellular therapy consisting of autologous T cells transduced with an anti-CD19 chimeric antigen receptor, after myeloablative chemotherapy (melphalan, 140 mg per square meter of body-surface area) and autologous stem-cell transplantation. Four years earlier, autologous transplantation with a higher melphalan dose (200 mg per square meter) had induced only a partial, transient response. Autologous transplantation f ...[more]