Dataset Information

Vascular endothelial growth factor D expression is a potential biomarker of bevacizumab benefit in colorectal cancer.

ABSTRACT:

Background

Bevacizumab prolongs progression-free survival (PFS) in patients with metastatic colorectal cancer. We analysed the protein expression levels of vascular endothelial growth factor (VEGF) ligands and receptors to determine their prognostic and predictive effects.

Methods

We graded expression of VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-R1, and VEGF-R2 to assess whether overexpression predicted bevacizumab resistance in samples from 268 of 471 patients randomised to capecitabine (C), capecitabine and bevacizumab (CB), or CB and mitomycin (CBM) in the MAX trial and extended the analysis to the CAIRO-2 population.

Results

Patients with low expression of VEGF-D (0, 1þ) benefited from bevacizumab treatment (PFS hazard ratio (HR) (C vs CBþCBM), 0.21; 95% CI, 0.08–0.55; overall survival (OS) HR, 0.35; 95% CI, 0.13–0.90). Patients with higher VEGF-D expression received less benefit (VEGF-D 2þ PFS HR, 0.67; 95% CI, 0.45–1.00; OS HR, 0.82; 95% CI, 0.52–1.30; VEGF-D 3þ PFS HR, 0.77; 95% CI, 0.50–1.17; OS HR, 1.28; 95% CI, 0.79–2.09) (P interaction o0.05). In CAIRO-2, there was no difference in PFS or OS according to VEGF-D expression.

Conclusions

The predictive value of VEGF-D expression for bevacizumab may depend on the chemotherapy backbone used. Further evaluation is required before clinical utilisation.

SUBMITTER: Weickhardt AJ

PROVIDER: S-EPMC4647541 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Publications

Vascular endothelial growth factor D expression is a potential biomarker of bevacizumab benefit in colorectal cancer.

Weickhardt A J AJ Williams D S DS Lee C K CK Chionh F F Simes J J Murone C C Wilson K K Parry M M MM Asadi K K Scott A M AM Punt C J A CJ Nagtegaal I D ID Price T J TJ Mariadason J M JM Tebbutt N C NC

British journal of cancer 20150601 1

<h4>Background</h4>Bevacizumab prolongs progression-free survival (PFS) in patients with metastatic colorectal cancer. We analysed the protein expression levels of vascular endothelial growth factor (VEGF) ligands and receptors to determine their prognostic and predictive effects.<h4>Methods</h4>We graded expression of VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-R1, and VEGF-R2 to assess whether overexpression predicted bevacizumab resistance in samples from 268 of 471 patients randomised to capecitabi ...[more]

PMID: 26125443

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Dataset Information

Vascular endothelial growth factor D expression is a potential biomarker of bevacizumab benefit in colorectal cancer.

Background

Methods

Results

Conclusions

Publications

Vascular endothelial growth factor D expression is a potential biomarker of bevacizumab benefit in colorectal cancer.

Similar Datasets

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