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NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and ?-Ketoamides.

ABSTRACT: The efficient asymmetric synthesis of highly substituted succinimides from ?,?-unsaturated aldehydes and ?-ketoamides via NHC-catalyzed [3+2] cycloaddition has been developed. The new scalable protocol significantly expands the utility of NHC catalysis for the synthesis of heterocycles and provides easy access to assemble a wide range of succinimides from simple starting materials.

SUBMITTER: Wang L

PROVIDER: S-EPMC4648042 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and α-Ketoamides.

Wang Lei L Ni Qijian Q Blümel Marcus M Shu Tao T Raabe Gerhard G Enders Dieter D

Chemistry (Weinheim an der Bergstrasse, Germany) 20150415 22

The efficient asymmetric synthesis of highly substituted succinimides from α,β-unsaturated aldehydes and α-ketoamides via NHC-catalyzed [3+2] cycloaddition has been developed. The new scalable protocol significantly expands the utility of NHC catalysis for the synthesis of heterocycles and provides easy access to assemble a wide range of succinimides from simple starting materials. ...[more]

PMID: 25877658

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