Ontology highlight
ABSTRACT:
SUBMITTER: Lee CU
PROVIDER: S-EPMC4648047 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Lee Chang-Uk CU Hahne Gernot G Hanske Jonas J Bange Tanja T Bier David D Rademacher Christoph C Hennig Sven S Grossmann Tom N TN
Angewandte Chemie (International ed. in English) 20150929 46
PTEN is a dual-specificity protein tyrosine phosphatase. As one of the central tumor suppressors, a thorough regulation of its activity is essential for proper cellular homeostasis. The precise implications of PTEN inhibition by reactive oxygen species (e.g. H2 O2 ) and the subsequent structural consequences remain elusive. To study the effects of PTEN inhibition, bisperoxidovanadium (bpV) complexes serve as important tools with the potential for the treatment of nerve injury or cardiac ischemia ...[more]