Ontology highlight
ABSTRACT:
SUBMITTER: Aliperta R
PROVIDER: S-EPMC4648523 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Aliperta R R Cartellieri M M Feldmann A A Arndt C C Koristka S S Michalk I I von Bonin M M Ehninger A A Bachmann J J Ehninger G G Bornhäuser M M Bachmann M P MP
Blood cancer journal 20150918
Bispecific antibodies (bsAbs) engaging T cells are emerging as a promising immunotherapeutic tool for the treatment of hematologic malignancies. Because their low molecular mass, bsAbs have short half-lives. To achieve clinical responses, they have to be infused into patients continously, for a long period of time. As a valid alternative we examined the use of mesenchymal stromal cells (MSCs) as autonomous cellular machines for the constant production of a recently described, fully humanized ant ...[more]