Ontology highlight
ABSTRACT:
SUBMITTER: Chao J
PROVIDER: S-EPMC4648714 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
The Journal of investigative dermatology 20150826 12
The fibroblast-populated three-dimensional (3-D) collagen matrix has been used to model matrix contraction, cell motility, and general fibroblast biology. MCPIP1 (monocyte chemotactic protein-induced protein 1) has been shown to regulate inflammation, angiogenesis, and cellular motility. In the present study, we demonstrated induction of MCPIP1 in human fibroblasts embedded in the stress-released 3-D collagen matrix, which occurred through activation of mitogen-activated protein kinases, phospho ...[more]