MCPIP1 Regulates Fibroblast Migration in 3-D Collagen Matrices Downstream of MAP Kinases and NF-?B.
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ABSTRACT:
SUBMITTER: Chao J
PROVIDER: S-EPMC4648714 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
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MCPIP1 Regulates Fibroblast Migration in 3-D Collagen Matrices Downstream of MAP Kinases and NF-κB.
Chao Jie J Dai Xiaoniu X Peña Tiffany T Doyle David A DA Guenther Timothy M TM Carlson Mark A MA
The Journal of investigative dermatology 20150826 12
The fibroblast-populated three-dimensional (3-D) collagen matrix has been used to model matrix contraction, cell motility, and general fibroblast biology. MCPIP1 (monocyte chemotactic protein-induced protein 1) has been shown to regulate inflammation, angiogenesis, and cellular motility. In the present study, we demonstrated induction of MCPIP1 in human fibroblasts embedded in the stress-released 3-D collagen matrix, which occurred through activation of mitogen-activated protein kinases, phospho ...[more]
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