Ontology highlight
ABSTRACT:
SUBMITTER: Belenky P
PROVIDER: S-EPMC4648786 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Belenky Peter P Ye Jonathan D JD Porter Caroline B M CB Cohen Nadia R NR Lobritz Michael A MA Ferrante Thomas T Jain Saloni S Korry Benjamin J BJ Schwarz Eric G EG Walker Graham C GC Collins James J JJ
Cell reports 20151022 5
Understanding how antibiotics impact bacterial metabolism may provide insight into their mechanisms of action and could lead to enhanced therapeutic methodologies. Here, we profiled the metabolome of Escherichia coli after treatment with three different classes of bactericidal antibiotics (?-lactams, aminoglycosides, quinolones). These treatments induced a similar set of metabolic changes after 30 min that then diverged into more distinct profiles at later time points. The most striking changes ...[more]