Ontology highlight
ABSTRACT:
SUBMITTER: Ryan TE
PROVIDER: S-EPMC4649016 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Ryan Terence E TE Schmidt Cameron A CA Green Tom D TD Brown David A DA Neufer P Darrell PD McClung Joseph M JM
Frontiers in physiology 20151118
Critical limb ischemia (CLI) is the most severe clinical presentation of peripheral arterial disease and manifests as chronic limb pain at rest and/or tissue necrosis. Current clinical interventions are largely ineffective and therapeutic angiogenesis based trials have shown little efficacy, highlighting the dire need for new ideas and novel therapeutic approaches. Despite a decade of research related to skeletal muscle as a determinant of morbidity and mortality outcomes in CLI, very little pro ...[more]