Ontology highlight
ABSTRACT:
SUBMITTER: Tan Y
PROVIDER: S-EPMC4649138 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Tan Yuan Y AlKhamees Bodour B Jia Deyong D Li Li L Couture Jean-François JF Figeys Daniel D Jinushi Masahisa M Wang Lisheng L
Stem cell reports 20151008 5
The molecules and mechanisms pertinent to the low immunogenicity of undifferentiated embryonic stem cells (ESCs) remain poorly understood. Here, we provide evidence that milk fat globule epidermal growth factor 8 (MFG-E8) is a vital mediator in this phenomenon and directly suppresses T cell immune responses. MFG-E8 is enriched in undifferentiated ESCs but diminished in differentiated ESCs. Upregulation of MFG-E8 in ESCs increases the successful engraftment of both undifferentiated and differenti ...[more]