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Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.


ABSTRACT: We investigated the susceptibility of 10 enterovirus D68 (EV-D68) isolates (belonging to clusters A, B, and C) to (entero)virus inhibitors with different mechanisms of action. The 3C-protease inhibitors proved to be more efficient than enviroxime and pleconaril, which in turn were more effective than vapendavir and pirodavir. Favipiravir proved to be a weak inhibitor. Resistance to pleconaril maps to V69A in the VP1 protein, and resistance to rupintrivir maps to V104I in the 3C protease. A structural explanation of why both substitutions may cause resistance is provided.

SUBMITTER: Sun L 

PROVIDER: S-EPMC4649165 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.

Sun Liang L   Meijer Adam A   Froeyen Mathy M   Zhang Linlin L   Thibaut Hendrik Jan HJ   Baggen Jim J   George Shyla S   Vernachio John J   van Kuppeveld Frank J M FJ   Leyssen Pieter P   Hilgenfeld Rolf R   Neyts Johan J   Delang Leen L  

Antimicrobial agents and chemotherapy 20150914 12


We investigated the susceptibility of 10 enterovirus D68 (EV-D68) isolates (belonging to clusters A, B, and C) to (entero)virus inhibitors with different mechanisms of action. The 3C-protease inhibitors proved to be more efficient than enviroxime and pleconaril, which in turn were more effective than vapendavir and pirodavir. Favipiravir proved to be a weak inhibitor. Resistance to pleconaril maps to V69A in the VP1 protein, and resistance to rupintrivir maps to V104I in the 3C protease. A struc  ...[more]

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