Ontology highlight
ABSTRACT:
SUBMITTER: Sun L
PROVIDER: S-EPMC4649165 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Sun Liang L Meijer Adam A Froeyen Mathy M Zhang Linlin L Thibaut Hendrik Jan HJ Baggen Jim J George Shyla S Vernachio John J van Kuppeveld Frank J M FJ Leyssen Pieter P Hilgenfeld Rolf R Neyts Johan J Delang Leen L
Antimicrobial agents and chemotherapy 20150914 12
We investigated the susceptibility of 10 enterovirus D68 (EV-D68) isolates (belonging to clusters A, B, and C) to (entero)virus inhibitors with different mechanisms of action. The 3C-protease inhibitors proved to be more efficient than enviroxime and pleconaril, which in turn were more effective than vapendavir and pirodavir. Favipiravir proved to be a weak inhibitor. Resistance to pleconaril maps to V69A in the VP1 protein, and resistance to rupintrivir maps to V104I in the 3C protease. A struc ...[more]