Roflumilast, a Type 4 Phosphodiesterase Inhibitor, Shows Promising Adjunctive, Host-Directed Therapeutic Activity in a Mouse Model of Tuberculosis.
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SUBMITTER: Maiga MC
PROVIDER: S-EPMC4649180 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
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Roflumilast, a Type 4 Phosphodiesterase Inhibitor, Shows Promising Adjunctive, Host-Directed Therapeutic Activity in a Mouse Model of Tuberculosis.
Maiga Mariama C MC Ahidjo Bintou Ahmadou BA Maiga Mamoudou M Bishai William R WR
Antimicrobial agents and chemotherapy 20151005 12
With phosphodiesterase inhibitors (PDE-Is) showing significant promise in shortening tuberculosis treatment, we assessed the effect of roflumilast, an FDA-approved type 4 PDE-I, in both acute and chronic murine models of tuberculosis. Alone, roflumilast had no effect on lung bacillary burden and mortality. However, when roflumilast was used in combination with isoniazid, a reduction in lung bacillary burden was observed. These data suggest that roflumilast may be a good candidate for tuberculosi ...[more]
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