Ontology highlight
ABSTRACT:
SUBMITTER: Fullgrabe A
PROVIDER: S-EPMC4649262 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Füllgrabe Anja A Joost Simon S Are Alexandra A Jacob Tina T Sivan Unnikrishnan U Haegebarth Andrea A Linnarsson Sten S Simons Benjamin D BD Clevers Hans H Toftgård Rune R Kasper Maria M
Stem cell reports 20151101 5
The dynamics and interactions between stem cell pools in the hair follicle (HF), sebaceous gland (SG), and interfollicular epidermis (IFE) of murine skin are still poorly understood. In this study, we used multicolor lineage tracing to mark Lgr6⁺ -expressing basal cells in the HF isthmus, SG, and IFE.We show that these Lgr6⁺ cells constitute long-term self-renewing populations within each compartment in adult skin. Quantitative analysis of clonal dynamics revealed that the Lgr6⁺ progenitor cells ...[more]