Ontology highlight
ABSTRACT:
SUBMITTER: Kataoka K
PROVIDER: S-EPMC4650542 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Kataoka K K Matsumoto H H Kaneko H H Notomi S S Takeuchi K K Sweigard J H JH Atik A A Murakami Y Y Connor K M KM Terasaki H H Miller J W JW Vavvas D G DG
Cell death & disease 20150423
Detachment of photoreceptors from the retinal pigment epithelium is seen in various retinal disorders, resulting in photoreceptor death and subsequent vision loss. Cell death results in the release of endogenous molecules that activate molecular platforms containing caspase-1, termed inflammasomes. Inflammasome activation in retinal diseases has been reported in some cases to be protective and in others to be detrimental, causing neuronal cell death. Moreover, the cellular source of inflammasome ...[more]