Ontology highlight
ABSTRACT:
SUBMITTER: Antony J
PROVIDER: S-EPMC4650611 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Antony Jayesh J Saikia Minakshi M Vinod V V Nath Lekshmi R LR Katiki Mohana Rao MR Murty M S R MS Paul Anju A Shabna A A Chandran Harsha H Joseph Sophia Margaret SM Nishanth Kumar S KS Panakkal Elizabeth Jayex EJ Sriramya I V I Sridivya I V I Ran Sophia S Sankar S S Rajan Easwary E Anto Ruby John RJ
Scientific reports 20150610
Wrightia tinctoria is a constituent of several ayurvedic preparations against skin disorders including psoriasis and herpes, though not yet has been explored for anticancer potential. Herein, for the first time, we report the significant anticancer properties of a semi-purified fraction, DW-F5, from the dichloromethane extract of W. tinctoria leaves against malignant melanoma. DW-F5 exhibited anti-melanoma activities, preventing metastasis and angiogenesis in NOD-SCID mice, while being non-toxic ...[more]