Ontology highlight
ABSTRACT:
SUBMITTER: Zheng Q
PROVIDER: S-EPMC4650625 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Zheng Qingliang Q Hou Jin J Zhou Ye Y Yang Yingyun Y Xie Bing B Cao Xuetao X
Cell research 20150911 10
Type I interferon (IFN) production plays pivotal roles in host antiviral innate immune responses, but an excessive production of type I IFN leads to the development of immunopathological conditions. Investigations on the regulatory mechanisms underlying host type I IFN production are currently of great interest. Here, we found that the expression of lectin family member Siglec1 was upregulated by viral infection in macrophages, which was dependent on the IFN/JAK/STAT1 signaling pathway. Siglec1 ...[more]