Ontology highlight
ABSTRACT:
SUBMITTER: Hecht I
PROVIDER: S-EPMC4650638 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Hecht Inbal I Bar-El Yasmin Y Balmer Frederic F Natan Sari S Tsarfaty Ilan I Schweitzer Frank F Ben-Jacob Eshel E
Scientific reports 20150527
Metastasizing tumor cells migrate through the surrounding tissue and extracellular matrix toward the blood vessels, in order to colonize distant organs. They typically move in a dense environment, filled with other cells. In this work we study cooperative effects between neighboring cells of different types, migrating in a maze-like environment with directional cue. Using a computerized model, we measure the percentage of cells that arrive to the defined target, for different mesenchymal/amoeboi ...[more]