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Treating progressive multifocal leukoencephalopathy with interleukin 7 and vaccination with JC virus capsid protein VP1.

ABSTRACT: Progressive multifocal leukoencephalopathy is a currently untreatable infection of the brain. Here, we demonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as adjuvant, was well tolerated, and showed a very favorable safety profile and unexpected efficacy that warrant further investigation.

SUBMITTER: Sospedra M 

PROVIDER: S-EPMC4650775 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Treating progressive multifocal leukoencephalopathy with interleukin 7 and vaccination with JC virus capsid protein VP1.

Sospedra Mireia M   Schippling Sven S   Yousef Sara S   Jelcic Ilijas I   Bofill-Mas Silvia S   Planas Raquel R   Stellmann Jan-Patrick JP   Demina Viktoria V   Cinque Paola P   Garcea Robert R   Croughs Therese T   Girones Rosina R   Martin Roland R  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20140911 11

Progressive multifocal leukoencephalopathy is a currently untreatable infection of the brain. Here, we demonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as adjuvant, was well tolerated, and showed a very favorable safety profile and unexpected efficacy that warrant further investigation. ...[more]

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