Dataset Information

Female breast cancer incidence among Asian and Western populations: more similar than expected.

ABSTRACT:

Background

Previous reports suggested that female breast cancer is associated with earlier ages at onset among Asian than Western populations. However, most studies utilized cross-sectional analyses that may be confounded by calendar-period and/or birth cohort effects. We, therefore, considered a longitudinal (forward-looking) approach adjusted for calendar-period changes and conditioned upon birth cohort.

Methods

Invasive female breast cancer data (1988-2009) were obtained from cancer registries in China, Hong Kong, South Korea, Taiwan, Singapore, and the United States. Age-period-cohort models were used to extrapolate longitudinal age-specific incidence rates for the 1920, 1944, and 1970 birth cohorts.

Results

Cross-sectional age-specific incidence rates rose continuously until age 80 years among US white women, but plateaued or decreased after age 50 years among Asian women. In contrast, longitudinal age-specific rates were proportional (similar) among all Asian countries and the United States with incidence rates rising continuously until age 80 years. The extrapolated estimates for the most recent cohorts in some Asian countries actually showed later ages at onset than in the United States. Additionally, over successive birth cohorts, the incidence rate ratios (IRRs) for the longitudinal curves converged (narrowed) between Asian and US white women.

Conclusions

Similar longitudinal age-specific incidence rates along with converging IRRs indicate that the age effects for invasive breast cancer are more similar among Asian and Western populations than might be expected from a solely cross-sectional analysis. Indeed, the Asian breast cancer rates in recent generations are even surpassing the historically high rates in the United States, highlighting an urgent need for efficient prevention and treatment strategies among Asian populations.

SUBMITTER: Sung H

PROVIDER: S-EPMC4651040 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Female breast cancer incidence among Asian and Western populations: more similar than expected.

Sung Hyuna H Rosenberg Philip S PS Chen Wan-Qing WQ Hartman Mikael M Lim Wei-Yen WY Chia Kee Seng KS Wai-Kong Mang Oscar O Chiang Chun-Ju CJ Kang Daehee D Ngan Roger Kai-Cheong RK Tse Lap Ah LA Anderson William F WF Yang Xiaohong R XR

Journal of the National Cancer Institute 20150413 7

<h4>Background</h4>Previous reports suggested that female breast cancer is associated with earlier ages at onset among Asian than Western populations. However, most studies utilized cross-sectional analyses that may be confounded by calendar-period and/or birth cohort effects. We, therefore, considered a longitudinal (forward-looking) approach adjusted for calendar-period changes and conditioned upon birth cohort.<h4>Methods</h4>Invasive female breast cancer data (1988-2009) were obtained from c ...[more]

PMID: 25868578

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Dataset Information

Female breast cancer incidence among Asian and Western populations: more similar than expected.

Background

Methods

Results

Conclusions

Publications

Female breast cancer incidence among Asian and Western populations: more similar than expected.

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