Ontology highlight
ABSTRACT:
SUBMITTER: Pashayan N
PROVIDER: S-EPMC4651137 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Pashayan Nora N Pharoah Paul Dp PD Schleutker Johanna J Talala Kirsi K Tammela Teuvo Lj TLj Määttänen Liisa L Harrington Patricia P Tyrer Jonathan J Eeles Rosalind R Duffy Stephen W SW Auvinen Anssi A
British journal of cancer 20150820 7
<h4>Background</h4>We derived estimates of overdiagnosis by polygenic risk groups and examined whether polygenic risk-stratified screening for prostate cancer reduces overdiagnosis.<h4>Methods</h4>We calculated the polygenic risk score based on genotypes of 66 known prostate cancer loci for 4967 men from the Finnish section of the European Randomised Study of Screening for Prostate Cancer. We stratified the 72 072 men in the trial into those with polygenic risk below and above the median. Using ...[more]