Variations in the Intragene Methylation Profiles Hallmark Induced Pluripotency.

ABSTRACT: We demonstrate the potential of differentiating embryonic and induced pluripotent stem cells by the regularized linear and decision tree machine learning classification algorithms, based on a number of intragene methylation measures. The resulting average accuracy of classification has been proven to be above 95%, which overcomes the earlier achievements. We propose a constructive and transparent method of feature selection based on classifier accuracy. Enrichment analysis reveals statistically meaningful presence of stemness group and cancer discriminating genes among the selected best classifying features. These findings stimulate the further research on the functional consequences of these differences in methylation patterns. The presented approach can be broadly used to discriminate th

SUBMITTER: Druzhkov P 

PROVIDER: S-EPMC4651640 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature