Unknown

Dataset Information

0

Amphiregulin Is a Critical Downstream Effector of Estrogen Signaling in ER?-Positive Breast Cancer.

ABSTRACT: Estrogen stimulation promotes epithelial cell proliferation in estrogen receptor (ER?)-positive breast cancer. Many ER? target genes have been enumerated, but the identities of the key effectors mediating the estrogen signal remain obscure. During mouse mammary gland development, the estrogen growth factor receptor (EGFR) ligand amphiregulin acts as an important stage-specific effector of estrogen signaling. In this study, we investigated the role of amphiregulin in breast cancer cell proliferation using human tissue samples and tumor xenografts in mice. Amphiregulin was enriched in ER?-positive human breast tumor cells and required for estrogen-dependent growth of MCF7 tumor xenografts. Furthermore, amphiregulin levels were suppressed in patients treated with endocrine therapy. Suppression of EGF receptor signaling appeared necessary for the therapeutic response in this setting. Our findings implicate amphiregulin as a critical mediator of the estrogen response in ER?-positive breast cancer, emphasizing the importance of EGF receptor signaling in breast tumor pathogenesis and therapeutic response.

SUBMITTER: Peterson EA 

PROVIDER: S-EPMC4651747 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Amphiregulin Is a Critical Downstream Effector of Estrogen Signaling in ERα-Positive Breast Cancer.

Peterson Esther A EA   Jenkins Edmund C EC   Lofgren Kristopher A KA   Chandiramani Natasha N   Liu Hui H   Aranda Evelyn E   Barnett Maryia M   Kenny Paraic A PA  

Cancer research 20151102 22

Estrogen stimulation promotes epithelial cell proliferation in estrogen receptor (ERα)-positive breast cancer. Many ERα target genes have been enumerated, but the identities of the key effectors mediating the estrogen signal remain obscure. During mouse mammary gland development, the estrogen growth factor receptor (EGFR) ligand amphiregulin acts as an important stage-specific effector of estrogen signaling. In this study, we investigated the role of amphiregulin in breast cancer cell proliferat  ...[more]

Similar Datasets

Unknown ER-α36-mediated rapid estrogen signaling positively regulates ER-positive breast cancer stem/progenitor cells.
| S-EPMC3928099 | biostudies-literature
Unknown EPRS is a critical regulator of cell proliferation and estrogen signaling in ER+ breast cancer.
| S-EPMC5342500 | biostudies-literature
Unknown Estrogen receptor (ER) was regulated by RNPC1 stabilizing mRNA in ER positive breast cancer.
| S-EPMC4494937 | biostudies-literature
Unknown Apigenin, a Partial Antagonist of the Estrogen Receptor (ER), Inhibits ER-Positive Breast Cancer Cell Proliferation through Akt/FOXM1 Signaling.
| S-EPMC7796491 | biostudies-literature
Unknown Spatiotemporal control of estrogen-responsive transcription in ER?-positive breast cancer cells.
| S-EPMC4865474 | biostudies-literature
Unknown An estrogen receptor (ER)-related signature in predicting prognosis of ER-positive breast cancer following endocrine treatment.
| S-EPMC6652714 | biostudies-literature
Unknown A kinetic model identifies phosphorylated estrogen receptor-? (ER?) as a critical regulator of ER? dynamics in breast cancer.
| S-EPMC4415015 | biostudies-literature
Unknown Effects of SDF-1-CXCR4 signaling on microRNA expression and tumorigenesis in estrogen receptor-alpha (ER-?)-positive breast cancer cells.
| S-EPMC3334320 | biostudies-literature
Transcriptomics EPRS is a Critical Regulator of Cell Proliferation and Estrogen Signaling in ER+ Breast Cancer
2016-10-05 | GSE81162 | GEO
Proteomics Validation dataset on tamoxifen treated Estrogen Receptor (ER) positive breast cancer patients
2015-08-21 | PXD000485 | Pride