Ontology highlight
ABSTRACT:
SUBMITTER: Lim K
PROVIDER: S-EPMC4651804 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Lim Kihong K Hyun Young-Min YM Lambert-Emo Kris K Topham David J DJ Kim Minsoo M
Journal of immunological methods 20150902
β2 integrins play critical roles in migration of immune cells and in the interaction with other cells, pathogens, and the extracellular matrix. Among the β2 integrins, Mac-1 (Macrophage antigen-1), composed of CD11b and CD18, is mainly expressed in innate immune cells and plays a major role in cell migration and trafficking. In order to image Mac-1-expressing cells both in live cells and mouse, we generated a knock-in (KI) mouse strain expressing CD11b conjugated with monomeric yellow fluorescen ...[more]