Ontology highlight
ABSTRACT:
SUBMITTER: Sewald X
PROVIDER: S-EPMC4651917 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Sewald Xaver X Ladinsky Mark S MS Uchil Pradeep D PD Beloor Jagadish J Pi Ruoxi R Herrmann Christin C Motamedi Nasim N Murooka Thomas T TT Brehm Michael A MA Greiner Dale L DL Shultz Leonard D LD Mempel Thorsten R TR Bjorkman Pamela J PJ Kumar Priti P Mothes Walther W
Science (New York, N.Y.) 20151001 6260
Dendritic cells can capture and transfer retroviruses in vitro across synaptic cell-cell contacts to uninfected cells, a process called trans-infection. Whether trans-infection contributes to retroviral spread in vivo remains unknown. Here, we visualize how retroviruses disseminate in secondary lymphoid tissues of living mice. We demonstrate that murine leukemia virus (MLV) and human immunodeficiency virus (HIV) are first captured by sinus-lining macrophages. CD169/Siglec-1, an I-type lectin tha ...[more]