Ontology highlight
ABSTRACT:
SUBMITTER: Mairhofer DG
PROVIDER: S-EPMC4652066 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Mairhofer David G DG Ortner Daniela D Tripp Christoph H CH Schaffenrath Sandra S Fleming Viktor V Heger Lukas L Komenda Kerstin K Reider Daniela D Dudziak Diana D Chen Suzie S Becker Jürgen C JC Flacher Vincent V Stoitzner Patrizia P
The Journal of investigative dermatology 20150629 11
Murine tumor models that closely reflect human diseases are important tools to investigate carcinogenesis and tumor immunity. The transgenic (tg) mouse strain tg(Grm1)EPv develops spontaneous melanoma due to ectopic overexpression of the metabotropic glutamate receptor 1 (Grm1) in melanocytes. In the present study, we characterized the immune status and functional properties of immune cells in tumor-bearing mice. Melanoma development was accompanied by a reduction in the percentages of CD4(+) T ...[more]