Body mass index and risk of lung cancer: Systematic review and dose-response meta-analysis.

ABSTRACT: Questions remain about the significance of the dose-response relationship between body mass index (BMI) and lung cancer (LC) risk. Pertinent studies were identified through a search in EMBASE and PUBMED from July 2014 until March 2015. The summary relative risk (SRR) and confidence interval (CI) were estimated. The dose-response relationship was assessed using a restricted cubic spline. The overall meta-analysis showed evidence of a nonlinear association between BMI and LC risk (Pnonlinearity??0.05), whereas the effects were attenuated when restricting analysis to non-smokers, and at the point of 30?kg/m(2), the SRR was 0.96 (95%CI: 0.86-1.07) for males and 0.95 (95%CI: 0.89-1.02) for females. This meta-analysis provides quantitative evidence that increasing BMI is a protective factor against LC. Keeping normal-to-moderate BMI should be prescribed as an evidence-based lifestyle tip for LC prevention in smokers.

SUBMITTER: Duan P 

PROVIDER: S-EPMC4652238 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature