Ontology highlight
ABSTRACT:
SUBMITTER: Chang D
PROVIDER: S-EPMC4652271 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Chang Di D Wang Yuan-Cheng YC Bai Ying-Ying YY Lu Chun-Qiang CQ Xu Ting-Ting TT Zhu Lei L Ju Shenghong S
Scientific reports 20151119
Matrix metalloproteinases (MMPs) exert a dual effect in ischemic stroke and thus represent an ideal target for detection and therapy. However, to date, all clinical trials of MMP inhibitors have failed, and alternative drug candidates and therapeutic targets are urgently required. Nonetheless, further investigations are limited by the lack of non-invasive imaging techniques. Here, we report a novel, fast and ultrasensitive MMP activatable optical imaging probe for the dynamic visualization of MM ...[more]