Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC4652320 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Li Yi Y Tsui Wai W Rusinek Henry H Butler Tracy T Mosconi Lisa L Pirraglia Elizabeth E Mozley David D Vallabhajosula Shankar S Harada Ryuichi R Furumoto Shozo S Furukawa Katsutoshi K Arai Hiroyuki H Kudo Yukitsuka Y Okamura Nobuyuki N de Leon Mony J MJ
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20150108 2
<h4>Unlabelled</h4>Neurofibrillary tau pathology and amyloid β (Aβ) plaques, characteristic lesions of Alzheimer disease (AD), show different neocortical laminar distributions. Neurofibrillary-tangle tau pathology tends to be closer to the gray matter-white matter boundary, whereas Aβ is dispersed throughout the width of the cortical ribbon.<h4>Methods</h4>Using PET radiotracers for tau and Aβ lesions, we developed an image analysis tool to measure the distance of tracer-positive voxels from the ...[more]