Ontology highlight
ABSTRACT:
SUBMITTER: Yunn NO
PROVIDER: S-EPMC4652772 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Yunn Na-Oh NO Koh Ara A Han Seungmin S Lim Jong Hun JH Park Sehoon S Lee Jiyoun J Kim Eui E Jang Sung Key SK Berggren Per-Olof PO Ryu Sung Ho SH
Nucleic acids research 20150805 16
Due to their high affinity and specificity, aptamers have been widely used as effective inhibitors in clinical applications. However, the ability to activate protein function through aptamer-protein interaction has not been well-elucidated. To investigate their potential as target-specific agonists, we used SELEX to generate aptamers to the insulin receptor (IR) and identified an agonistic aptamer named IR-A48 that specifically binds to IR, but not to IGF-1 receptor. Despite its capacity to stim ...[more]