Ontology highlight
ABSTRACT:
SUBMITTER: Depeille P
PROVIDER: S-EPMC4652934 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Depeille Philippe P Henricks Linda M LM van de Ven Robert A H RA Lemmens Ed E Wang Chih-Yang CY Matli Mary M Werb Zena Z Haigis Kevin M KM Donner David D Warren Robert R Roose Jeroen P JP
Nature cell biology 20150525 6
The character of EGFR signals can influence cell fate but mechanistic insights into intestinal EGFR-Ras signalling are limited. Here we show that two distinct Ras nucleotide exchange factors, RasGRP1 and SOS1, lie downstream of EGFR but act in functional opposition. RasGRP1 is expressed in intestinal crypts where it restricts epithelial growth. High RasGRP1 expression in colorectal cancer (CRC) patient samples correlates with a better clinical outcome. Biochemically, we find that RasGRP1 creates ...[more]