Ontology highlight
ABSTRACT:
SUBMITTER: Chen H
PROVIDER: S-EPMC4653017 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Oncotarget 20150801 24
Axon guidance protein Semaphorin 3E (Sema3E) promotes tumor metastasis and suppresses tumor cell death. Here, we demonstrated that Sema3E was decreased in gastric cancer. Its levels were inversely associated with tumor progression. Levels of Sema3E were associated with low p300 and high class I histone deacetylase (class I HDAC). Ectopic expression of Sema3E inhibited proliferation and colony formation of gastric cancer cell lines in vitro and xenografts in vivo. Sema3E overexpression inhibited ...[more]